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AVANDIA | Rosiglitazone




Avandia® Side Effects Lawsuit

Avandia (Generic: Rosiglitazone), a popular drug used by millions of Americans to treat Type 2 diabetes has been linked to the following life-threatening and serious side effects: congestive heart failure, heart attack, stroke, blindness, vision loss, macular edema, and bone fractures.

What is the problem?

The controversy surrounding Avandia began when The New England Journal of Medicine (NEJM) published a combined analysis of more than 40 studies that evaluated approximately 28,000 Avandia patients.

The results of the studies were shocking … One of the studies showed that Avandia, made by GlaxoSmithKline, doubled the risks of heart failure and raised the risks of heart attack by 42 percent.

The main author of the NEJM article, Dr. Sonal Singh, has also stated, “In addition to its deleterious effects on the heart, Avandia can cause blindness, and it doubles the risks of bone fractures in women.”

U.S. Food & Drug Administration “Black Box Warning”

After Dr. Singh’s article was published, the FDA stated that it had been evaluating the drug’s risks and issued a safety alert advising Avandia patients to consult their doctors.

The New York Times reported, “In the study’s aftermath, the drug agency said that it had been told in 2005 of a similar study conducted by GlaxoSmithKline, the manufacturer of Avandia that came to a similar conclusion. Critics denounced the agency’s delay in alerting patients.”

After a review of postmarketing adverse event reports, the FDA determined that an updated label with a boxed warning on the risks of heart failure was needed for the entire thiazolidinedione class of antidiabetic drugs.

The drugs affected by the FDA Black Box Warning are as follows:

  • Avandia® (rosiglitazone maleate) Tablets
  • Actos® (pioglitazone hydrochloride) Tablets
  • Avandaryl® (rosiglitazone maleate and glimepiride) Tablets
  • Avandamet® (rosiglitazone maleate and metformin hydrochloride) Tablets
  • Duetact® (pioglitazone hydrochloride and glimepride) Tablets

The strengthened warning advises healthcare professionals to observe patients carefully for the signs and symptoms of heart failure, including excessive, rapid weight gain, shortness of breath, and edema after starting drug therapy. Patients with these symptoms who then develop heart failure should receive appropriate management of the heart failure and use of the drug should be reconsidered. People who have questions should contact their healthcare providers to discuss alternative treatments.

Avandia Side Effects

  • Congestive Heart Failure
  • Heart Attack
  • Stroke
  • Blindness
  • Vision loss
  • Macular Edema
  • Bone Fractures

FDA Video: Stronger Warnings on Avandia and Certain Diabetes Drugs

Below is an excellent video published by the U.S. Food & Drug Administration (FDA), which warns patients and physicians of  stronger warnings on Avandia et.al regarding the link between the drugs and the increased risk of heart failure.


Do I Have an AVANDIA Lawsuit?

If you or somebody you know has used AVANDIA and since suffered from an adverse event, you should contact us immediately at 512-233-1129 or simply fill out the form below. You may be entitled to compensation by filing a AVANDIA lawsuit and we can help.

 

Avandia®

Case Manager Form

Please fill out the form below to contact our firm regarding your case:

Have you or a loved one taken Avandia or Rosiglitazone ? YES
  NO

 
First Name: *
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What were the dates of use? (if applicable)
Have you been diagnosed with any of the following medical conditions (please select all that apply)
Heart Attack
  Congestive Heart Failure
  Liver Complications
  Macular Adema
  Stroke
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